R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles

To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to exami...

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Detalhes bibliográficos
Main Authors: Finlay, Liam A., Michels, Alex J., Butler, Judy A., Smith, Eric J., Monette, Jeffrey S., Moreau, Régis F., Petersen, Shay Kate, Frei, Balz, Hagen, Tory M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Obesity, Diabetes and Energy Homeostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311522/
https://ncbi.nlm.nih.gov/pubmed/22049228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00393.2011
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