R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles

To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver tissue was analyzed by Affymetrix microarray to exami...

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Autori principali: Finlay, Liam A., Michels, Alex J., Butler, Judy A., Smith, Eric J., Monette, Jeffrey S., Moreau, Régis F., Petersen, Shay Kate, Frei, Balz, Hagen, Tory M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2012
Soggetti:
Obesity, Diabetes and Energy Homeostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311522/
https://ncbi.nlm.nih.gov/pubmed/22049228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00393.2011
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