(R)-α-Lipoic Acid Treatment Restores Ceramide Balance in Aging Rat Cardiac Mitochondria

Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics, we hypothesized that mitochondrial decay stems par...

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Huvudupphovsmän: Monette, Jeffrey S., Gómez, Luis A., Moreau, Régis F., Dunn, Kevin C., Butler, Judy A., Finlay, Liam A., Michels, Alexander J., Shay, Kate Petersen, Smith, Eric J., Hagen, Tory M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268156/
https://ncbi.nlm.nih.gov/pubmed/20934512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2010.09.007
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