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Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

HSCs undergo dramatic changes with aging. An increase in absolute numbers of HSCs along with a functional deficit in reconstitution potential and a shift toward production of myeloid cells are the hallmarks of murine hematopoietic aging. Here, we show that high levels of the inflammatory cytokine Ra...

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Bibliografski detalji
Glavni autori: Ergen, Aysegul V., Boles, Nathan C., Goodell, Margaret A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311273/
https://ncbi.nlm.nih.gov/pubmed/22289892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391730
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