Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings

The effects of mGlu1 and mGlu5 receptor activation on the depolarization-evoked release of [(3)H]D-aspartate ([(3)H]D-ASP) from mouse cortical synaptosomes were investigated. The mGlu1/5 receptor agonist 3,5-DHPG (0.1–100 μM) potentiated the K(+)(12 μM)-evoked [(3)H]D-ASP overflow. The potentiation...

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Bibliografiske detaljer
Main Authors: Musante, Veronica, Neri, Elisa, Feligioni, Marco, Puliti, Aldamaria, Pedrazzi, Marco, Conti, Valerio, Usai, Cesare, Diaspro, Alberto, Ravazzolo, Roberto, Henley, Jeremy M., Battaglia, Giuseppe, Pittaluga, Anna
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310906/
https://ncbi.nlm.nih.gov/pubmed/18625255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.06.056
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