Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

BACKGROUND: Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and is typified by the loss of spinal cord motor neurons, muscular atrophy, and in severe cases, death. The SMN protein is ubiquitous...

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Hlavní autoři: Bowerman, Melissa, Murray, Lyndsay M, Boyer, Justin G, Anderson, Carrie L, Kothary, Rashmi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310724/
https://ncbi.nlm.nih.gov/pubmed/22397316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-24
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