Mouse STAT2 Restricts Early Dengue Virus Replication

Dengue virus encodes several interferon antagonists. Among these the NS5 protein binds STAT2, a necessary component of the type-I interferon signaling pathway, and targets it for degradation. We now demonstrate that the ability of dengue NS5 to associate with and degrade STAT2 is species specific. T...

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Hauptverfasser: Ashour, Joseph, Morrison, Juliet, Laurent-Rolle, Maudry, Belicha-Villanueva, Alan, Plumlee, Courtney Ray, Bernal-Rubio, Dabeiba, Williams, Kate, Harris, Eva, Fernandez-Sesma, Ana, Schindler, Christian, García-Sastre, Adolfo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310429/
https://ncbi.nlm.nih.gov/pubmed/21075352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.10.007
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