Co-factors Required for TLR7- and TLR9- dependent Innate Immune Responses

Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded nucleic acids to initiate MyD88-dependent pro-inflammatory responses to microbial infection. Using genome-wide RNAi screening and integrative syste...

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Autori principali: Chiang, Chih-yuan, Engel, Alex, Opaluch, Amanda M., Ramos, Irene, Maestre, Ana M., Secundino, Ismael, De Jesus, Paul D., Nguyen, Quy T., Welch, Genevieve, Bonamy, Ghislain M.C., Miraglia, Loren J., Orth, Anthony P., Nizet, Victor, Fernandez-Sesma, Ana, Zhou, Yingyao, Barton, Gregory M., Chanda, Sumit K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310399/
https://ncbi.nlm.nih.gov/pubmed/22423970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.02.002
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