Reagents for astatination of biomolecules. 6. An intact antibody conjugated with a maleimido-closo-decaborate(2-) reagent via sulfhydryl groups had considerably higher kidney concentrations than the same antibody conjugated with an isothiocyanato-closo-decaborate(2-) reagent via lysine amines

We are investigating the use of an (211)At-labeled anti-CD45 monoclonal antibody (mAb) as a replacement of total body irradiation in conditioning regimens designed to decrease the toxicity of hematopoietic cell transplantation (HCT). As part of that investigation, dose-escalation studies were conduc...

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Main Authors: Wilbur, D. Scott, Chyan, Ming-Kuan, Nakamae, Hirohisa, Chen, Yun, Hamlin, Donald K., Santos, Erlinda B., Kornblit, Brian T., Sandmaier, Brenda M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310299/
https://ncbi.nlm.nih.gov/pubmed/22296587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200401b
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