Induction of Protective CD4(+) T Cell-Mediated Immunity by a Leishmania Peptide Delivered in Recombinant Influenza Viruses

The available evidence suggests that protective immunity to Leishmania is achieved by priming the CD4(+) Th1 response. Therefore, we utilised a reverse genetics strategy to generate influenza A viruses to deliver an immunogenic Leishmania peptide. The single, immunodominant Leishmania-specific LACK(...

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Main Authors: Kedzierska, Katherine, Curtis, Joan M., Valkenburg, Sophie A., Hatton, Lauren A., Kiu, Hiu, Doherty, Peter C., Kedzierski, Lukasz
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310046/
https://ncbi.nlm.nih.gov/pubmed/22470440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033161
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