Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

Tolerance to self-antigens present in apoptotic cells is critical to maintain immune-homeostasis and prevent systemic autoimmunity. However, mechanisms that sustain self-tolerance are poorly understood. Here we show that systemic administration of apoptotic cells to mice induced splenic expression o...

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Main Authors: Ravishankar, Buvana, Liu, Haiyun, Shinde, Rahul, Chandler, Phillip, Baban, Babak, Tanaka, Masato, Munn, David H., Mellor, Andrew L., Karlsson, Mikael C. I., McGaha, Tracy L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309765/
https://ncbi.nlm.nih.gov/pubmed/22355111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117736109
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