NR4A1 (Nur77) Deletion Polarizes Macrophages Towards an Inflammatory Phenotype and Increases Atherosclerosis

RATIONALE: NR4A1 (Nur77) is a nuclear receptor that is expressed in macrophages and within atherosclerotic lesions, yet its function in atherosclerosis is unknown. OBJECTIVE: Nur77 regulates the development of monocytes, particularly patrolling Ly6C(−) monocytes that may be involved in resolution of...

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Autors principals: Hanna, Richard N., Shaked, Iftach, Hubbeling, Harper G., Punt, Jennifer A., Wu, Runpei, Herrley, Erica, Zaugg, Claudia, Pei, Hong, Geissmann, Frederic, Ley, Klaus, Hedrick, Catherine C.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309661/
https://ncbi.nlm.nih.gov/pubmed/22194622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.253377
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