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Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self- reactive T cells

The Nur77/Nurr1 family of DNA binding proteins has been reported to be required for the signal transduction of CD3/T cell receptor (TCR)- mediated apoptosis in T cell hybridomas. To determine the role of this family of DNA-binding proteins in thymic clonal deletion, transgenic (Tg) mice bearing a do...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1996
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192482/
https://ncbi.nlm.nih.gov/pubmed/8666944
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