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Regulation of T cell receptor β allelic exclusion by gene segment proximity and accessibility(,2)
Antigen receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well understood. Assembly of a functional T cell receptor (TCR) β chain gene triggers feedback inhibition of V(β)-to-DJ(β) recombination in double positive (DP) thymocytes which correlates with reduced V(β)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309396/ https://ncbi.nlm.nih.gov/pubmed/22079986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102611 |
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