Incorporation of 2,3-diaminopropionic acid in linear cationic amphipathic peptides produces pH sensitive vectors

Non-viral vectors that harness the change in pH in endosomes are increasingly being used to deliver cargoes, including nucleic acids, to mammalian cells. Here we present evidence that the pKa of the β-NH(2) in 2,3-diaminopropionic acid (Dap) is sufficiently lowered, when incorporated in peptides, th...

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Detalhes bibliográficos
Main Authors: Lan, Yun, Langlet-Bertin, Bérangère, Abbate, Vincenzo, Vermeer, Louic S., Kong, Xiaole, Sullivan, Kelly E., Leborgne, Christian, Scherman, Daniel, Hider, Robert C., Drake, Alex F., Bansal, Sukhvinder S., Kichler, Antoine, Mason, A. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309271/
https://ncbi.nlm.nih.gov/pubmed/20480482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201000073
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