Effect of Oxidative Stress on Protein Tyrosine Phosphatase-1B in Scleroderma Dermal Fibroblasts

OBJECTIVE: Platelet-derived growth factor (PDGF) and its receptor (PDGFR) promote fibrosis in scleroderma (SSc) dermal fibroblasts, which produce excessive reactive oxygen species (ROS). PDGFR is phosphorylated upon PDGF stimulation, and dephosphorylated by protein tyrosine phosphatases (PTPs), incl...

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Hlavní autoři: Tsou, Pei-Suen, Talia, Nadine N., Pinney, Adam J., Kendzicky, Ann, Piera-Velazquez, Sonsoles, Jimenez, Sergio A., Seibold, James R., Phillips, Kristine, Koch, Alisa E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309078/
https://ncbi.nlm.nih.gov/pubmed/22161819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34336
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