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Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans
The DAF-2 Insulin/IGF-1 signaling (IIS) pathway is a strong modifier of Caenorhabditis elegans longevity and healthspan. As aging is the greatest risk factor for developing neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), we were interested in determining if DAF-2 signaling mo...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308959/ https://ncbi.nlm.nih.gov/pubmed/22457769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033494 |
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