5, 8, 11, 14-eicosatetraynoic acid suppresses CCL2/MCP-1 expression in IFN-γ-stimulated astrocytes by increasing MAPK phosphatase-1 mRNA stability

BACKGROUND: The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes; however, its underlying mechanism of action is largely unknown. In the present stud...

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Autores principales: Lee, Jee Hoon, Kim, Hyunmi, Woo, Joo Hong, Joe, Eun-hye, Jou, Ilo
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308915/
https://ncbi.nlm.nih.gov/pubmed/22339770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-34
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