The Mycobacterium tuberculosis Stress Response Factor SigH Is Required for Bacterial Burden as Well as Immunopathology in Primate Lungs

(See the editorial commentary by Kernodle, on pages 1186–8.) Background. Sigma H (sigH) is a major Mycobacterium tuberculosis (Mtb) stress response factor. It is induced in response to heat, oxidative stress, cell wall damage, and hypoxia. Infection of macrophages with the Δ-sigH mutant generates mo...

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Autori principali: Mehra, Smriti, Golden, Nadia A., Stuckey, Kerstan, Didier, Peter J., Doyle, Lara A., Russell-Lodrigue, Kasi E., Sugimoto, Chie, Hasegawa, Atsuhiko, Sivasubramani, Satheesh K., Roy, Chad J., Alvarez, Xavier, Kuroda, Marcelo J., Blanchard, James L., Lackner, Andrew A., Kaushal, Deepak
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308902/
https://ncbi.nlm.nih.gov/pubmed/22402035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis102
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