Polyubiquitination of Insulin-like Growth Factor I Receptor (IGF-IR) Activation Loop Promotes Antibody-induced Receptor Internalization and Down-regulation

Ubiquitination has been implicated in negatively regulating insulin-like growth factor I receptor (IGF-IR) activity. Because of the relative stability of IGF-IR in the presence of ligand stimulation, IGF-IR ubiquitination sites have yet to be mapped and characterized, thus preventing a direct demons...

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Main Authors: Mao, Yifan, Shang, Yonglei, Pham, Victoria C., Ernst, James A., Lill, Jennie R., Scales, Suzie J., Zha, Jiping
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308891/
https://ncbi.nlm.nih.gov/pubmed/21994939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288514
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