Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting

LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates lentiviral integration site preference. In this study we determined the role of the PWWP domain of LEDGF/p75 in tethering and targeting of the lentiviral pre-integration complex, employing potent knockdown cell li...

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Bibliografske podrobnosti
Main Authors: Gijsbers, Rik, Vets, Sofie, De Rijck, Jan, Ocwieja, Karen E., Ronen, Keshet, Malani, Nirav, Bushman, Frederic D., Debyser, Zeger
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308889/
https://ncbi.nlm.nih.gov/pubmed/21987578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255711
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