Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling

The CXCL12/CXCR4 signaling axis plays an important role in human health and disease; however, the molecular mechanisms mediating CXCR4 signaling remain poorly understood. Ubiquitin modification of CXCR4 by the E3 ubiquitin ligase AIP4 is required for lysosomal sorting and degradation, which is media...

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Autores principales: Malik, Rohit, Soh, Unice J. K., Trejo, JoAnn, Marchese, Adriano
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308791/
https://ncbi.nlm.nih.gov/pubmed/22275353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.336792
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