Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor

The type 1 corticotropin-releasing hormone receptor (CRH-R1) influences biological responses important for adaptation to stressful stimuli, through activation of multiple downstream effectors. The structural motifs within CRH-R1 that mediate G protein activation and signaling selectivity are unknown...

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Bibliografiske detaljer
Main Authors: Punn, Anu, Chen, Jing, Delidaki, Maria, Tang, Jiyou, Liapakis, George, Lehnert, Hendrik, Levine, Michael A., Grammatopoulos, Dimitris K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308756/
https://ncbi.nlm.nih.gov/pubmed/22247544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272161
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