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Identification of Mechanism That Couples Multisite Phosphorylation of Yes-associated Protein (YAP) with Transcriptional Coactivation and Regulation of Apoptosis

The transcriptional coactivator Yes-associated protein (YAP) has been implicated in tumorigenesis by regulating cell proliferation and apoptosis. YAP interacts with the transcription factor TEAD and is essential in mediating TEAD-dependent gene expression. Here we show that YAP is hyperphosphorylate...

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書目詳細資料
Main Authors: Lee, Kyung-Kwon, Yonehara, Shin
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308740/
https://ncbi.nlm.nih.gov/pubmed/22308035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296954
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