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Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP
The Hippo signaling pathway suppresses cell proliferation and tumorigenesis. In the canonical Hippo pathway, large tumor suppressor kinases 1/2 (LATS1/2) phosphorylate the transcriptional coactivator yes-associated protein (YAP) and thereby suppress its nuclear localization and co-transcriptional ac...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7062186/ https://ncbi.nlm.nih.gov/pubmed/31996378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010783 |
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