Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis

Sequencing targeted DNA regions in large samples is necessary to discover the full spectrum of rare variants. We report an effective Illumina sequencing strategy utilizing pooled samples with novel quality (Srfim) and filtering (SERVIC(4)E) algorithms. We sequenced 24 exons in two cohorts of 480 sam...

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Detalhes bibliográficos
Main Authors: Niranjan, Tejasvi S, Adamczyk, Abby, Bravo, Héctor Corrada, Taub, Margaret A, Wheelan, Sarah J, Irizarry, Rafael, Wang, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308056/
https://ncbi.nlm.nih.gov/pubmed/21955804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-9-r93
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