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Mutation discovery in mice by whole exome sequencing
We report the development and optimization of reagents for in-solution, hybridization-based capture of the mouse exome. By validating this approach in a multiple inbred strains and in novel mutant strains, we show that whole exome sequencing is a robust approach for discovery of putative mutations,...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308049/ https://ncbi.nlm.nih.gov/pubmed/21917142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-9-r86 |
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