Mild Hypothermia Decreases Fentanyl and Midazolam Steady-State clearance in a Rat Model of Cardiac Arrest

OBJECTIVES: Therapeutic hypothermia is widely-employed for neuroprotection after cardiac arrest(CA). However, concern regarding elevated drug concentrations during hypothermia and increased adverse drug reaction risk complicates concurrent pharmacotherapy. Many commonly used medications in criticall...

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Bibliographic Details
Main Authors: Empey, Philip E., Miller, Tricia M., Philbrick, Ashley H., Melick, John, Kochanek, Patrick M., Poloyac, Samuel M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307845/
https://ncbi.nlm.nih.gov/pubmed/22067624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e31823779f9
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