THERAPEUTIC HYPOTHERMIA DECREASES PHENYTOIN ELIMINATION IN CHILDREN WITH TRAUMATIC BRAIN INJURY

OBJECTIVE: Preclinical and clinical studies have suggested that therapeutic hypothermia, while decreasing neurological injury, may also lead to drug toxicity that may limit its benefit. Cooling decreases cytochrome p450(CYP)-mediated drug metabolism and limited clinical data suggest that drug levels...

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Auteurs principaux: Empey, Philip E., Velez de Mendizabal, Nieves, Bell, Michael J., Bies, Robert R., Anderson, Kacey B., Kochanek, Patrick M., Adelson, P. David, Poloyac, Samuel M.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783553/
https://ncbi.nlm.nih.gov/pubmed/23896831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e318292316c
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