PGH(1), the Precursor for the Anti-Inflammatory Prostaglandins of the 1-series, Is a Potent Activator of the Pro-Inflammatory Receptor CRTH2/DP2

Prostaglandin H(1) (PGH(1)) is the cyclo-oxygenase metabolite of dihomo-γ-linolenic acid (DGLA) and the precursor for the 1-series of prostaglandins which are often viewed as “anti-inflammatory”. Herein we present evidence that PGH(1) is a potent activator of the pro-inflammatory PGD(2) receptor CRT...

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Detalhes bibliográficos
Main Authors: Schröder, Ralf, Xue, Luzheng, Konya, Viktoria, Martini, Lene, Kampitsch, Nora, Whistler, Jennifer L., Ulven, Trond, Heinemann, Akos, Pettipher, Roy, Kostenis, Evi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307725/
https://ncbi.nlm.nih.gov/pubmed/22442685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033329
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