Antagonism of the prostaglandin D(2 )receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

BACKGROUND: Mast cell-derived prostaglandin D(2 )(PGD(2)), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH(2 )cells (CRTH2), a high affinity receptor for prostaglandin D(2), mediates trafficking of TH(2...

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Autors principals: Uller, Lena, Mathiesen, Jesper Mosolff, Alenmyr, Lisa, Korsgren, Magnus, Ulven, Trond, Högberg, Thomas, Andersson, Gunnar, Persson, Carl GA, Kostenis, Evi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1810525/
https://ncbi.nlm.nih.gov/pubmed/17328802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-8-16
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