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Statistical Inference of In Vivo Properties of Human DNA Methyltransferases from Double-Stranded Methylation Patterns

DNA methyltransferases establish methylation patterns in cells and transmit these patterns over cell generations, thereby influencing each cell's epigenetic states. Three primary DNA methyltransferases have been identified in mammals: DNMT1, DNMT3A and DNMT3B. Extensive in vitro studies have in...

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Detalhes bibliográficos
Main Authors: Fu, Audrey Q., Genereux, Diane P., Stöger, Reinhard, Burden, Alice F., Laird, Charles D., Stephens, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307717/
https://ncbi.nlm.nih.gov/pubmed/22442664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032225
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