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Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent inhibitors of cholesterol-5,6-epoxide hydrolase (ChEH), which led to the accumulation of 5,6α-epoxy-cholesterol (5,6α-EC) and 5,6β-epoxy-cholesterol (5,6β-EC). This could b...

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Main Authors: Paillasse, Michael R., Saffon, Nathalie, Gornitzka, Heinz, Silvente-Poirot, Sandrine, Poirot, Marc, de Medina, Philippe
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307648/
https://ncbi.nlm.nih.gov/pubmed/22285872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M023689
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