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Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide
Sifuvirtide (SFT) is an electrostatically constrained α-helical peptide fusion inhibitor showing potent anti-HIV activity, good safety, and pharmacokinetic profiles, and it is currently under phase II clinical trials in China. In this study, we demonstrate its potent and broad anti-HIV activity by u...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307288/ https://ncbi.nlm.nih.gov/pubmed/22228771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.317883 |
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