Dynamic Mechanism of Proton Transfer in Mannitol 2-Dehydrogenase from Pseudomonas fluorescens: MOBILE GLU(292) CONTROLS PROTON RELAY THROUGH A WATER CHANNEL THAT CONNECTS THE ACTIVE SITE WITH BULK SOLVENT

The active site of mannitol 2-dehydrogenase from Pseudomonas fluorescens (PfM2DH) is connected with bulk solvent through a narrow protein channel that shows structural resemblance to proton channels utilized by redox-driven proton pumps. A key element of the PfM2DH channel is the “mobile” Glu(292),...

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Detalles Bibliográficos
Main Authors: Klimacek, Mario, Brunsteiner, Michael, Nidetzky, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307286/
https://ncbi.nlm.nih.gov/pubmed/22194597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289223
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