Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis

Abietadiene synthase from Abies grandis (AgAS) is a model system for diterpene synthase activity, catalyzing class I (ionization-initiated) and class II (protonation-initiated) cyclization reactions. Reported here is the crystal structure of AgAS at 2.3 Å resolution and molecular dynamics simulation...

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Hlavní autoři: Zhou, Ke, Gao, Yang, Hoy, Julie A., Mann, Francis M., Honzatko, Richard B., Peters, Reuben J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307272/
https://ncbi.nlm.nih.gov/pubmed/22219188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337592
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