Acridine Yellow G Blocks Glioblastoma Growth via Dual Inhibition of Epidermal Growth Factor Receptor and Protein Kinase C Kinases

Amplification of the epidermal growth factor receptor (EGFR), frequently expressed as a constitutively active deletion mutant (EGFRvIII), occurs commonly in glioblastoma multiformes (GBM). However, blockade of EGFR is therapeutically disappointing for gliomas with PTEN deletion. To search for small...

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Detalhes bibliográficos
Main Authors: Qi, Qi, He, Kunyan, Yoo, Min-Heui, Chan, Chi-Bun, Liu, Xia, Zhang, Zhaobin, Olson, Jeffrey J., Xiao, Ge, Wang, Liya, Mao, Hui, Fu, Haian, Tao, Hui, Ramalingam, Suresh S., Sun, Shi-Yong, Mischel, Paul S., Ye, Keqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307261/
https://ncbi.nlm.nih.gov/pubmed/22215664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293605
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