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Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions

Oxidative damage by myeloperoxidase (MPO) has been proposed to deprive HDL of its cardioprotective effects. In vitro studies reveal that MPO chlorinates and nitrates specific tyrosine residues of apoA-I, the major HDL protein. After Tyr-192 is chlorinated, apoA-I is less able to promote cholesterol...

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書誌詳細
主要な著者: Shao, Baohai, Pennathur, Subramaniam, Heinecke, Jay W.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307260/
https://ncbi.nlm.nih.gov/pubmed/22219194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337345
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