Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions

Oxidative damage by myeloperoxidase (MPO) has been proposed to deprive HDL of its cardioprotective effects. In vitro studies reveal that MPO chlorinates and nitrates specific tyrosine residues of apoA-I, the major HDL protein. After Tyr-192 is chlorinated, apoA-I is less able to promote cholesterol...

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Bibliographic Details
Main Authors: Shao, Baohai, Pennathur, Subramaniam, Heinecke, Jay W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307260/
https://ncbi.nlm.nih.gov/pubmed/22219194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337345
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