Angiotensin-II-dependent Hypertension Requires Cyclooxygenase 1-derived Prostaglandin E(2) and EP(1) Receptor Signaling in the Subfornical Organ of the Brain

Cyclooxygenase (COX)-derived prostanoids have long been implicated in blood pressure (BP) regulation. Recently prostaglandin E(2) (PGE(2)) and its receptor EP(1)R have emerged as key players in angiotensin II (Ang-II)-dependent hypertension (HTN) and related end-organ damage. However, the enzymatic...

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Autori principali: Cao, Xian, Peterson, Jeffrey R., Wang, Gang, Anrather, Josef, Young, Colin N., Guruju, Mallikarjuna R., Burmeister, Melissa A., Iadecola, Costantino, Davisson, Robin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307140/
https://ncbi.nlm.nih.gov/pubmed/22371360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.182071
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