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Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks
Transmission of HIV strains with drug-resistance mutations (DRMs) causes public health problems in resource-rich countries. We use a stochastic model, with data from viral competition experiments, to analyze the effect of fitness costs (FCs) and genetic bottlenecks on limiting transmission of 10 cli...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307053/ https://ncbi.nlm.nih.gov/pubmed/22432052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00320 |
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