Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated Tau protein, and (3) amyloid plaques. Genetically, AD is linked to mutations in few proteins...

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Detalhes bibliográficos
Main Authors: Nizzari, Mario, Thellung, Stefano, Corsaro, Alessandro, Villa, Valentina, Pagano, Aldo, Porcile, Carola, Russo, Claudio, Florio, Tullio
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306972/
https://ncbi.nlm.nih.gov/pubmed/22496686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/187297
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