Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated Tau protein, and (3) amyloid plaques. Genetically, AD is linked to mutations in few proteins...

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Hlavní autoři: Nizzari, Mario, Thellung, Stefano, Corsaro, Alessandro, Villa, Valentina, Pagano, Aldo, Porcile, Carola, Russo, Claudio, Florio, Tullio
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
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Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306972/
https://ncbi.nlm.nih.gov/pubmed/22496686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/187297
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