Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling

Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated Tau protein, and (3) amyloid plaques. Genetically, AD is linked to mutations in few proteins...

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Main Authors: Nizzari, Mario, Thellung, Stefano, Corsaro, Alessandro, Villa, Valentina, Pagano, Aldo, Porcile, Carola, Russo, Claudio, Florio, Tullio
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Review Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306972/
https://ncbi.nlm.nih.gov/pubmed/22496686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/187297
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