Clozapine Impairs Insulin Action by Up-Regulating Akt Phosphorylation and Ped/Pea-15 Protein Abundance

Clinical and experimental evidence indicates that atypical antipsychotics impair glucose metabolism. We investigated whether clozapine may directly affect insulin action by analyzing insulin signaling in vitro and in vivo. Clozapine reduced insulin-stimulated glucose uptake in PC12 and in L6 cells,...

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Main Authors: Panariello, Fabio, Perruolo, Giuseppe, Cassese, Angela, Giacco, Ferdinando, Botta, Ginevra, Barbagallo, Alessia PM, Muscettola, Giovanni, Beguinot, Francesco, Formisano, Pietro, de Bartolomeis, Andrea
Format: Artigo
Jezik:Inglês
Izdano: Wiley Subscription Services, Inc., A Wiley Company 2012
Teme:
Original Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306790/
https://ncbi.nlm.nih.gov/pubmed/21618539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22864
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