Clozapine Impairs Insulin Action by Up-Regulating Akt Phosphorylation and Ped/Pea-15 Protein Abundance

Clinical and experimental evidence indicates that atypical antipsychotics impair glucose metabolism. We investigated whether clozapine may directly affect insulin action by analyzing insulin signaling in vitro and in vivo. Clozapine reduced insulin-stimulated glucose uptake in PC12 and in L6 cells,...

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Autors principals: Panariello, Fabio, Perruolo, Giuseppe, Cassese, Angela, Giacco, Ferdinando, Botta, Ginevra, Barbagallo, Alessia PM, Muscettola, Giovanni, Beguinot, Francesco, Formisano, Pietro, de Bartolomeis, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2012
Matèries:
Original Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306790/
https://ncbi.nlm.nih.gov/pubmed/21618539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22864
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