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First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development
Dose selection for “first in children” trials often relies on scaling of the pharmacokinetics from adults to children. Commonly used approaches are physiologically-based pharmacokinetic modeling (PBPK) and allometric scaling (AS) in combination with maturation of clearance for early life. In this in...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer US
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3306781/ https://ncbi.nlm.nih.gov/pubmed/22311388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-012-9241-9 |
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