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Total Synthesis of (±)–Rocaglamide via Oxidation-Initiated Nazarov Cyclization

[Image: see text] This article describes the evolution of a Nazarov cyclization-based synthetic strategy targeting the anticancer, antiinflammatory, and insecticidal natural product (±)–rocaglamide. Initial pursuit of a polarized heteroaromatic Nazarov cyclization to construct the congested cyclopen...

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Bibliographic Details
Main Authors: Malona, John A., Cariou, Kevin, Spencer, William T., Frontier, Alison J.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306619/
https://ncbi.nlm.nih.gov/pubmed/22283818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo202366c
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