Beta Defensin-2 Is Reduced in Central but Not in Distal Airways of Smoker COPD Patients

BACKGROUND: Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells crucially affect pulmonary defence mechanisms. METHO...

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Bibliographic Details
Main Authors: Pace, Elisabetta, Ferraro, Maria, Minervini, Marta Ida, Vitulo, Patrizio, Pipitone, Loredana, Chiappara, Giuseppina, Siena, Liboria, Montalbano, Angela Marina, Johnson, Malcolm, Gjomarkaj, Mark
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306426/
https://ncbi.nlm.nih.gov/pubmed/22438960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033601
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