Anthrax Lethal Toxin Disrupts Intestinal Barrier Function and Causes Systemic Infections with Enteric Bacteria

A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs). Using a murine...

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Autori principali: Sun, Chen, Fang, Hui, Xie, Tao, Auth, Roger D., Patel, Nayana, Murray, Patrick R., Snoy, Philip J., Frucht, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306423/
https://ncbi.nlm.nih.gov/pubmed/22438953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033583
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