Anthrax Lethal Toxin Disrupts Intestinal Barrier Function and Causes Systemic Infections with Enteric Bacteria

A variety of intestinal pathogens have virulence factors that target mitogen activated protein kinase (MAPK) signaling pathways, including Bacillus anthracis. Anthrax lethal toxin (LT) has specific proteolytic activity against the upstream regulators of MAPKs, the MAPK kinases (MKKs). Using a murine...

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Main Authors: Sun, Chen, Fang, Hui, Xie, Tao, Auth, Roger D., Patel, Nayana, Murray, Patrick R., Snoy, Philip J., Frucht, David M.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306423/
https://ncbi.nlm.nih.gov/pubmed/22438953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033583
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